Regulators of the transsulfuration pathway
نویسندگان
چکیده
منابع مشابه
Transsulfuration Pathway Thiols and Methylated Arginines: The Hunter Community Study
BACKGROUND Serum homocysteine, when studied singly, has been reported to be positively associated both with the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine [ADMA, via inhibition of dimethylarginine dimethylaminohydrolase (DDAH) activity] and with symmetric dimethylarginine (SDMA). We investigated combined associations between transsulfuration pathway thiols, including...
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The mammalian Hippo pathway plays pivotal roles in regulating organ size, stem cell pluripotency and tumorigenesis. In this pathway, the kinase Lats1/2, in complex with their regulatory subunit Mob, inhibit YAP and TAZ by a direct phosphorylation. YAP and TAZ are two main downstream effectors of the Hippo pathway, and they function as transcription co-activators to promote cell proliferation an...
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To permit an assessment of the relative contributions of the transsulfuration and the direct sulfhydration pathways for homocysteine biosynthesis, the time course of incorporation of (35)S from (35)SO(4) (2-) into various sulfur-containing compounds in Lemna paucicostata has been determined. Plants were grown with either low (4.5 micromolar) or ample (1,000 micromolar) sulfate in the medium. At...
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Control of cell number is crucial in animal development and tissue homeostasis, and its dysregulation may result in tumor formation or organ degeneration. The Hippo pathway in both Drosophila and mammals regulates cell number by modulating cell proliferation, cell death, and cell differentiation. Recently, numerous upstream components involved in the Hippo pathway have been identified, such as ...
متن کاملPlasma amino acids of the transsulfuration pathway and plasma lactate in septic patients.
OBJECTIVES In sepsis increasing plasma lactate, even if unrelated to hypoperfusion and hypoxia, is a cause of concern. Among the patterns associated with increasing lactate, several plasma amino acid (AA) abnormalities, more in particular those of sulfur AAs, have remained unexplored, and their assessment has been the purpose of our study. MATERIALS AND METHODS A systematic and detailed analy...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2018
ISSN: 0007-1188
DOI: 10.1111/bph.14446